Benzema put on another poor showing in the 3-0 defeat yesterday with Real Madrid now trailing Barcelona by 14 points at Christmas.
And Perez is furious with the players and is ready to wield the axe.
Benzema’s future was already uncertain but now it’s clear he will be sold – either in January or the summer.
Perez wants a new striker to lead his team with his eye on Mauro Icardi, Harry Kane and Kylian Mbappe.
The Frenchman has scored just twice in 12 La Liga appearances as Madrid sit fourth in the table.
They are out of the title race despite Zinedine Zidane insisting he doesn’t need to change anything.
Zidane is also under pressure and could be replaced during the winter break.
Meanwhile Perez is keen to axe Benzema along with two teammates – Casemiro and Mateo Kovacic – who also underperformed against Barcelona.